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- Removes freckles and dark spots
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
In 88.8% of patients, EEGs were normal or showed either diffuse high-frequency patterns or altered alertness, while in 5.1% of patients, EEGs showed interseizure epileptoid discharges and seizures (103)
Colestipol (decrease cobalamin and folate absorption) Methotrexate (inhibits DHFR) Nitrous Oxide (inactivates MS) High Dose Niacin (depletes SAMe and limits pyridoxal kinase = active B6) Theophylline (limits pyridoxal kinase = active B6) Cyclosporin A (decreases renal function and increases Hcy) Metformin (decreases cobalamin absorption) Phenytoin (folate antagonist) Carbamazepine (folate antagonist) Oral Contraceptives (deplete folate) Antimalarials JPC-2056, Pyrimethamine, Proguanil (inhibits DHFR) Antibiotic Trimethoprim (inhibits DHFR) Ethanol Bactrim (inhibits DHFR) Sulfasalazine (inhibits DHFR) Triamterene (inhibits DHFR) Involving yourself with providers who are educated on MTHFR Take supplements that are methylation supportive L-5-MTHF Riboflavin (B2) Methylcobalamin or Hydroxocobalamin Zinc DHA Choline TMG (must be avoided in pregnancy) Magnesium Methyl- B6 NAC Vitamin E (natural forms only) Selenium Glutathione Vitamin C Vitamin D Potassium Probiotics Molybdenum Milk Thistle *****Avoid gluten as 20% of patients with MTHFR have gluten sensitivity and gluten is inflammatory
The American Academy of Dermatology's 2023 expert consensus statement on oral minoxidil for hair loss does not mandate routine liver function testing, though it notes that baseline labs are "reasonable" for patients on concurrent hepatically metabolized medications [9]
Monoamine Oxidase (MAO) Inhibition: Although its clinical relevance is debated, at high doses amphetamine acts as a weak competitive inhibitor of monoamine oxidase, the mitochondrial enzyme responsible for degrading free cytosolic monoamines
